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The incidence of symptomatic documented arrhythmias over the duration of the study was also similar, although clinically significant arrhythmias were observed less frequently during Holter monitoring in the first 7 days with ranolazine group versus placebo.

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Gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) to confirm the presence of reversible exercise-induced left ventricular perfusion defect size (PDS) performed within 12 weeks prior to baseline or at the baseline visit, and at the end-of-period 1 and end-of-period 2 visits.

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Careful attention to the avoidance of dangerous interactive drug combinations would be helpful in reducing morbidity and mortality, as would careful medical screening to identify individuals idiosyncratically at risk of adverse effects.

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In patients with persisting symptoms despite optimal anti-ischaemic drug therapy, several other treatments have been proposed.

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Ranolazine increases QTc, and should therefore be used carefully in patients with QT prolongation or on QT-prolonging drugs.

It is recommended that those with inherited long QT syndrome not take any of the drugs on these lists.

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Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1).

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QT-prolonging drugs, potassium channel variants resulting in a long QT interval, in patients with a family history of (or congenital) long QT syndrome, or in patients with known acquired QT interval prolongation.

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At enrollment, patients will be randomized to ranolazine or placebo.

The risk of syncope and sudden death is decreased during pregnancy but increased in the postpartum period; the risk associated with the postpartum state appears to be increased among women with the LQT2 subtype as compared with women with the LQT1 or LQT3 subtype.

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