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Gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) to confirm the presence of reversible exercise-induced left ventricular perfusion defect size (PDS) performed within 12 weeks prior to baseline or at the baseline visit, and at the end-of-period 1 and end-of-period 2 visits.

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Ranolazine increases QTc, and should therefore be used carefully in patients with QT prolongation or on QT-prolonging drugs.

It is recommended that those with inherited long QT syndrome not take any of the drugs on these lists.

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QT-prolonging drugs, potassium channel variants resulting in a long QT interval, in patients with a family history of (or congenital) long QT syndrome, or in patients with known acquired QT interval prolongation.

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At enrollment, patients will be randomized to ranolazine or placebo.

The risk of syncope and sudden death is decreased during pregnancy but increased in the postpartum period; the risk associated with the postpartum state appears to be increased among women with the LQT2 subtype as compared with women with the LQT1 or LQT3 subtype.

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