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Of the 9541 remaining patients, 4645 were randomly assigned to receive 10 mg of ramipril once per day, 4652 were randomly assigned to receive matching placebo, and 244 were randomly assigned to receive a low dose (2.

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It has been proposed that AT 2 receptors mediate vasodilatation and nitric oxide (NO) release, effects that may counterbalance the AT 1-mediated effects, and that stimulation of the AT 2 receptor during AT 1 blockade with an ARB would result in dual benefits (antagonism of Ang II and increased NO).

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While taking ramipril, you should have your blood pressure checked regularly, along with tests of your kidney and liver functions.

Given this profile, the assumption early on, even before major clinical trials were conducted, was that ARBs would have similar if not greater systemic effects than might result from the use of ACEIs, because AT I blockade would offer a more complete inhibition of the RAS.

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These novel data also suggest that the perceived risk of RAS in such patients exceeds the actual risk and in the presence of a normal baseline creatinine no further assessment of renal function or imaging of the renal arteries is required prior to commencing ramipril.

Since we assume that kidney calcification and kidney stones are caused by the high levels of calcium in the urine, treatment typically is targeted at reducing those levels.

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Similarly, no benefit of combination therapy on the primary renal outcome (dialysis, doubling of serum creatinine, and death) was seen in participants with diabetic nephropathy; in the ONTARGET trial, the only benefit provided by dual RAS blockade was a greater reduction in urinary albumin excretion.

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