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06.09.2016, 02:00
Beitrag #1
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Changes in these post-translational modifications, for example in depression or upon antidepressant treatment, may then result in different GR phospho-isoforms, altered co-factor binding, and hence changes in GR-dependent gene transcription.

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However, it is important to segregate depressive symptoms and mood disturbances from neurocognitive impairment, as different biological mechanisms may be involved, as also shown by the differential effects of RU486 mentioned above.

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General measures for improving sleep hygiene, such as minimal use of caffeine, cigarettes, other stimulants and alcohol, maintaining a regular sleep schedule going to bed only when sleepy, regular exercise and avoiding daytime naps, should be explained to the patients.

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