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The following patients were excluded from the study: patients on medication for glaucoma, normal or low tension glaucoma, angle closure glaucoma patients with a history of intraocular surgery, diabetes mellitus, hypertension, bronchial asthma, ocular inflammation or infection in the preceding 3 months, conditions precluding Goldmann applanation tonometry, pregnant or lactating women, and patients that are sensitive to preservatives.

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The most frequently reported adverse reactions were eye pruritus, conjunctival hyperemia, skin hyperpigmentation, ocular irritation, dry eye symptoms, and periorbital erythema.

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Patients were excluded from participation if they had any of: i) a history of refractive surgery; ii) intraocular surgery within 3 months prior to baseline; iii) a visual field defect requiring medical intervention; iv) any contraindication to β-adrenoceptor antagonist therapy; v) any other known allergy or sensitivity to the study medications or their components; vi) any ocular inflammation or infection within 3 months prior to baseline, apart from mild blepharitis, or any history of uveitis; vii) any corneal abnormalities in either eye that would preclude accurate IOP readings with an applanation tonometer; viii) an ocular trauma in either eye within 6 months prior to baseline; ix) a requirement for chronic use during the study of ocular medications other than the study medications, in either eye; x) intermittent use of oral, injectable, or topical ophthalmic steroids within 21 days prior to baseline, or anticipated use during the study; xi) any other condition or situation that might put the subject at significant risk, confound the study results, or significantly impede participation.

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